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KMID : 0357220140260060436
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Journal of Korean Society Physical Therapy
2014 Volume.26 No. 6 p.436 ~ p.441
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The Effect of Transcranial Direct Current Stimulation on Cognitive Function and Biochemical Change of Rats with Alzheimer's Desease
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Kim Jin-Young
Park Seong-Doo
Song Hyun-Seung
Yang Kyung-Hee
Yu Seong-Hun
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Abstract
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Purpose: The objective of this study was to offer clinical primary data that it’ s aims to examine effects of transcranial direct current stimulation (tDCS) on cognitive function and biochemical change of rat with alzheimer’ s disease(AD) induced by injecting scopolamine.
Methods: Subjects were instructed cognitive dysfunction model, rat of Sprague-Dawley system was injected with scopolamine and each experimental group was classified into three; group Ⅰ (n=16) is non-treatment groups; group Ⅱ (n=16) is applied with the tacrine; group Ⅲ (n=16) is applied with the tDCS. The ziggurat task test was conducted to observe behavioral changes and cognitive function ability and 7, 14, 21, 28 days after the model. Acetylcholine Esterase (Ach E) activity was examined for biochemical assessment of which the results are followed.
Results: Participants showed as to behavioral change, tacrine application group was the most significantly responded, following tDCS application group. As to biochemical change, same as above, tacrine application group was the most significantly responded, following tDCS application group.
Conclusion: From these results, confirm that tDCS application to rat with alzheimer’ s disease leads to positive effects on
behavioral, cognitive function changes, and biochemical changes, lasting for certain period of time. This study, in particular, tDCS, which can change excitability of brain cells non-invasively, could provide basic data that is useful as a new treatment way for the patients with cognitive dysfunction.
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KEYWORD
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Acetylcholine Esterase, Alzheimer’s disease, Cognition
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